Look at those high risk areas. If there's
any chance you'll be traveling through them then take the pills with you. I think CDC is really good with the accuracy of detected threats and I personally trust advice from the organization.
I took malaria pills on my first trip overseas where there were risks in certain areas. Just in case, as I'm like you and have a tendency to wander off "the path". The drugs can definitely be hard on your body. I never touched them only b/c I didn't enter those high risk areas but felt better that I had them in case. It's really up to you tho.

Also, check out
Malaria Pills thread from the travel lounge for some other travelers' perspectives.